Voyage 200 (also V200 and Voyage 200 PLT) was released in 2002, being the replacement for the TI-92 Plus, with its only hardware upgrade over that calculator being an increase in the amount of flash memory available (2.7 megabytes for the Voyage 200 vs. 702 kilobytes for the TI-92 Plus). It also features a somewhat smaller and more rounded case design.

Like its predecessor, Voyage 200 is an advanced calculator that supports plotting multiple functions on the same graph, parametric, polar, 3D, and differential equation graphing as well as sequence representations. Its symbolic calculation system is based on a trimmed version of the calculation software Derive. In addition to its algebra and calculus capabilities, the Voyage 200 is packaged with list, spreadsheet, and data processing applications and can perform curve fitting to a number of standard functions and other statistical analysis operations. The calculator can also run most programs written for the TI-89 and TI-92 as well as programs specifically written for it. A large number of applications, ranging from games to interactive periodic tables can be found online.

The V200 is easily mistaken for a PDA or a small computer because of its massive enclosure and its full QWERTY keyboard — a feature which disqualifies the calculator for use in many tests and examinations, including the American ACT and SAT.